Ethyl cyanoglyoxylate-2-oxime (CAS: 3849-21-6), commonly recognized as Oxyma Pure, is a highly efficient and exceptionally safe coupling additive utilized in advanced peptide synthesis. As a superior, non-explosive alternative to traditional reagents like HOBt and HOAt, this specialized oxime compound significantly accelerates amide bond formation while effectively suppressing racemization. Manufactured under stringent quality control protocols, our industrial-grade intermediate ensures reliable batch-to-batch consistency and high coupling yields in both solid-phase and solution-phase synthesis. It serves as an indispensable chemical tool for sophisticated biochemical research and the large-scale commercial manufacturing of active pharmaceutical ingredients (APIs).