Facing HPMCAS and K30: Compact Size, Powerful Performance! — PPS TSE18 P+ Hot Melt Extrusion System Leads Domestic Breakthrough

As the pharmaceutical industry’s demand for advanced formulations like Amorphous Solid Dispersions (ASD) continues to grow, the ability to stably and efficiently process high-viscosity excipients such as HPMCAS (Hypromellose Acetate Succinate) and PVP K30 during hot melt extrusion has become a critical test of equipment capability. For years, Chinese pharmaceutical companies relied heavily on imported equipment for such challenging materials.

Now, Pharmaceutical Processing Technology Co., Ltd. (PPS) has broken through foreign technical barriers with its self-developed third-generation high-torque hot melt extrusion system — PPS TSE18 P+. This system delivers breakthrough production performance in high-viscosity systems like HPMCAS and K30, achieving "domestic superiority" in multiple domestic and international production lines.

PPS TSE18 P+: The High-Performance Representative of Domestic Hot Melt Extrusion

·Target Users: Pilot and commercial production

·Core Advantages: Wide high-torque process window (ideal for high-viscosity systems), compact design for space savings, seamless upstream/downstream integration

Customer Test 1:

For high-viscosity HPMCAS, PPS TSE18 P+ effortlessly achieves 15 kg/h output (torque ~50%) with stable 8-hour/day operation for 4 consecutive days.

Customer Feedback:

"Thanks to General Manager Yang’s hot melt extruder, we achieved stable 100 kg-level production for HPMCAS systems, truly realizing a leapfrog advancement for domestic equipment!"

Customer Test 2:

For high-viscosity PVP K30, PPS TSE18 P+ achieves 20 kg/h output!

During testing, a foreign client urgently asked:

"Can we purchase this equipment now?"

We replied: "This is our prototype, not for sale. We can provide new units!" Later, we learned that other suppliers’equipment failed to extrude K30 properly.

Why is PPS TSE18 P+ Ideal for Chinese Pharma?

Compact Design, Greater Flexibility

Parameter	PPS TSE18 P+
Dimensions	1400 × 765 × 1670 mm
Footprint	50% smaller than imported counterparts, ideal for compact GMP facilities and labs

Superior Performance, Broader Process Window

Key Metrics	Specifications
Torque	Up to 60 Nm (Ultra-H core)
Screw Speed	3-600 RPM
Temp Control	±1°C accuracy, 5 zones, up to 300°C
Output	5–15 kg/h (conservative estimate; actual depends on process/material)

High Integration, Turnkey Solutions

PPS TSE18 P+ integrates seamlessly with upstream feeding and downstream cooling/pelletizing systems for **continuous manufacturing**.

Cooling & Crushing: PPS CR100 Cooling Roller System Enhances Stability

The PPS CR100 Cooling Roller System pairs with TSE18 P+ to deliver product thickness as thick as 0.4 mm, outperforming imported alternatives.

Parameter	PPS CR100
Roller Configuration	φ128×200mm & φ64×200mm, independent speed control
Gap Adjustment	0.2–2 mm
Belt Width/Speed	218 mm, 0–5.7 m/min
Product Thickness	0.4–2 mm
Output	Max. ~20 kg/h
Control System	Siemens PLC & HMI
Dimensions	810 × 750 × 960 mm

Global Recognition: Domestic Equipment Winning International Trust

PPS systems are deployed in:

·Fosun Pharma, Huahai Pharma, Apeloa Pharma, XuanTai Pharma (China)

·Beijing University of Chinese Medicine Continuous Manufacturing Platform

·Production lines in India, Russia, and more

Summary: Compact & Powerful · Stable & Precise · Domestic & Superior

·Space-saving, flexible integration

·Broad process window for high-viscosity systems

·Full continuous manufacturing integration

·Local maintenance, cost efficiency, rapid response

Hot Melt Extrusion & Continuous Granulation — Choose PPS!

We provide complete solutions + scale-up guidance + localized support to elevate China’s pharma industry to global standards.