In today's rapidly developing pharmaceutical industry, efficiently and cost-effectively completing drug research and development as well as production is a common challenge faced by every enterprise. Suzhou PPS Technology Co., Ltd. (PPS), with over 20 years of technological accumulation and innovation, provides global clients with a comprehensive hot melt extrusion solution from R&D to mass production, simplifying complex processes into manageable ones. Whether it is precise exploration in laboratories, stable demands for large-scale production, or customized challenges in special scenarios, our products stand out as trustworthy partners with stable performance, energy-saving designs, and intelligent operating experiences. Next, let us focus on three core products and jointly explore the limitless possibilities of hot melt extrusion technology.

Ⅰ、PPS TSE Elf

Elf,Everyone who uses it says it's good!

In the early stages of drug development, researchers often face the challenge of limited or expensive active pharmaceutical ingredients (API) while needing to screen and optimize numerous formulations. To address this, PPS developed the PPS TSE Elf hot melt extrusion system, requiring only about 5 grams of material per experiment, significantly reducing experimental costs.

Keywords：

1.The smallest hot melt extrusion system in China!

2.Unique agile design, unparalleled precision!

3.A powerful tool for drug development!

Product Features：

1.Intermesh corotating twin-screw structure, scalable to pilot and production equipment；

2.Modular screw design for flexible adjustment for different formulations；

3.Little material consumption (only 5 grams per experiment)；

4.Small footprint；

5.Ultra-P temperature control system: precise temperature control (±1℃)；

6.Easy to install and disassemble, easy to clean；

7.Process parameters can be stored and exported for analysis.

Technical Parameters：

PPS TSE Elf
L/D Ratio (L/D)	20	Torque(Nm)	6
Diameter (mm)	8	Max. Power(KW)	0.5
Max.Speed(RPM)	300	Output (Kg/h)	0.005-0.05

*Specific output depends on specific processes and formulations

 

Ⅱ、PPS TSE16 P

The Highest Torque Pilot/Small-Scale Production System

In pharmaceutical formulation development, following the "Quality by Design" (QBD) principle, it is essential to explore the operational space that meets the product's critical quality attributes (CQA). For hot melt extrusion, this operational space depends on the system's torque—the greater the torque, the greater the process window. To meet this need, PPS developed the second-generation PPS TSE16 P hot melt extrusion system, offering a torque of up to 30Nm. This system can handle high-viscosity excipients, avoiding shutdown risks due to torque limits, and provides researchers with sufficient process window to find the best production processes ensuring product CQA.

 

Keywords：

1.China's first powerful hot melt extrusion system!

2.The highest torque pilot/small-scale production system in China!

3.High torque offers greater formulation/excipient screening possibilities!

Product Features：

1.High torque - 30Nm, can extrude almost all excipients smoothly (such as high-viscosity HPMCAS, PVP K30, etc.)；

2.Ultra-P temperature control system: precise temperature control (±1℃)；

3.Quick-connect design: easy installation and disassembly, can be cleaned as a whole；

4.Complete upstream (feeder) and downstream (cooling conveyor and pelletizing) equipment；

5.Small footprint: integrated design.

Technical Parameters：

PPS TSE Elf
L/D Ratio (L/D)	30	Torque(Nm)	30
Diameter (mm)	16	Max. Power(KW)	2
Max.Speed(RPM)	600	Output (Kg/h)	0.02-2

*Specific output depends on specific processes and formulations

Ⅲ、PPS TSE18 P+

The Most Powerful Hot Melt Extrusion System in China

The torque of a hot melt extrusion system is a key benchmark for measuring the technical level of an equipment supplier. The third-generation PPS TSE18 P+, newly developed by PPS, offers a torque of up to 60Nm, the highest in China. It can handle high-viscosity excipients (such as HPMCAS, PVP K30), avoiding shutdown risks due to torque limits, and provides a sufficient process window for large-scale drug production, ensuring stable quality during continuous production.

 

Keywords：

1.Torque climbs to 60Nm!

2.High torque provides a greater research and production process window, especially for amorphous solid dispersion products!

Product Features：

1.Integrated design: small footprint;

2.Ultra-P temperature control system: precise temperature control (±1℃);

3.Quick-connect design: easy installation and disassembly, can be cleaned as a whole;

4.Siemens touch screen control, can set user permissions and passwords, 5.process parameters (temperature and speed, etc.) can be stored and exported for analysis.

Technical Parameters：

PPS TSE Elf
L/D Ratio (L/D)	30	Torque(Nm)	60
Diameter (mm)	18	Max. Power(KW)	4
Max.Speed(RPM)	600	Output (Kg/h)	2-15

*Specific output depends on specific processes and formulations

 

From precise exploration in the laboratory to stable operations in production lines, PPS has always driven innovation in pharmaceutical processes through technological advancements. With profound industry experience and independent research and development capabilities, PPS is committed to becoming a leader in the global pharmaceutical hot melt extrusion sector, creating greater value for clients and setting technological benchmarks for the industry.